This mushroom is behind ‘tiny people’ hallucinations

Scientists have identified the mushroom behind “tiny people” hallucinations.

People in communities thousands of miles apart have described the same strange experience after eating a mysterious mushroom: vivid visions of tiny humans moving through and interacting with the physical world around them. Known as Lilliputian hallucinations—a reference to the 6-inch-tall inhabitants of Gulliver’s Travels—the phenomenon has long been thought to stem from cultural influences rather than biology.

A new study suggests otherwise.

Using DNA sequencing, University of Utah (U) researchers confirmed that a single mushroom species, Lanmaoa asiatica, is responsible for these hallucinations in Southwest China and the northern Philippines. They also discovered that the mushroom contains none of the psychoactive compounds known to science, including psilocybin.

Instead, the findings point to an entirely new hallucinogenic compound that could offer new insights into neurological disease and how the brain shapes perception and consciousness.

Colin Domnauer, a doctoral student at the U, and Bryn Dentinger, a mycologist at the U and the Natural History Museum of Utah, coauthored the study that appears in the journal Mycologia.

Here, Domnauer speaks about the Lilliputian mushroom, the decades-long mystery behind it, and the implications of a new hallucinogenic compound:

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How 1 sunburn can be ‘life-changing’

A severe sunburn can be painful and more serious than many people realize. But can one sunburn really be “life-changing”?

Unfortunately, the answer is yes.

What is a life-changing sunburn?

A “life-changing sunburn” is a phrase used to describe a severe sunburn, particularly one that causes blistering, because the damage it causes can have lifelong effects.

A sunburn occurs when ultraviolet (UV) radiation from the sun damages the DNA inside skin cells.

“When the body repairs that damage, mistakes can sometimes occur,” explains Adrienne Victor, oncologist at University of Rochester Medicine Wilmot Cancer Institute.

“Over time, these mutations can accumulate and contribute to the development of skin cancer.”

Research shows that blistering sunburns increase the risk of developing skin cancer later in life. For some types of skin cancer, even a single, severe, blistering sunburn can raise a person’s lifetime risk.

Children and teens may be particularly vulnerable to the long-term effects of severe sunburns.

“Children are more susceptible due to multiple risk factors, including the biology of their pigment-producing skin cells, the higher likelihood of sun exposure, and inconsistent use of sun protection,” says Jinia El-Feghaly, chief of pediatric dermatology at University of Rochester Medicine Golisano Children’s.

“Additionally, studies show that a higher frequency of sunburns during childhood is associated with a higher risk of skin cancer, even if sunburns become less frequent in adulthood.”

How to treat a severe sunburn

A mild sunburn may improve within a few days, while more severe burns can take a week or longer to heal. Cool compresses, plenty of fluids and appropriate moisturizers can help relieve discomfort.

Sunburn peeling is also common as damaged skin cells are shed. However, peeling does not mean the skin has fully recovered from the underlying damage.

Blistering is a sign of a more severe sunburn. Avoid popping blisters, which can increase the risk of infection. A health care provider should evaluate severe sunburn, especially when there is extensive blistering, severe pain, fever, or other concerning symptoms.

How to prevent sunburn and reduce skin cancer risk

The best way to prevent a life-changing sunburn is to protect skin from UV damage before it happens.

Protecting your skin doesn’t rely on one strategy alone. Experts recommend using several forms of sun protection whenever you’re outdoors, including:

• Broad-spectrum sunscreen
• Protective clothing
• Hats
• Shade
• Limiting time in direct sunlight, especially when UV levels are highest

Sunscreen is an important tool for reducing UV exposure. “Some people avoid sunscreen because of myths that its ingredients can cause skin cancer,” explains Victor. “However, the strongest evidence points to UV exposure as the primary cause of most skin cancers.”

The Fitzpatrick skin-type scale classifies skin based on how it typically responds to sun exposure, including how easily it burns or tans.

Although people with lower Fitzpatrick skin types are more likely to burn, skin cancer can affect people of every skin type. Everyone should take steps to protect their skin from UV exposure.

Source: University of Rochester

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The right message may get people to clean up the environment

People might be more inclined to keep their community clean if they believe it benefits them personally, according to new research.

The study found that focusing on how volunteering can benefit participants, such as by providing a new way to meet people or stay active, may encourage people to grab a trash bag and get to work.

“When we think about messaging, sometimes we think we’re going to get attention if we tell people they’ll lose something, right? But the messages we generate might have a broader impact if they’re positive,” says Jennifer Gay, corresponding author of the study and an associate professor in the University of Georgia College of Public Health.

“When messages and themes related to future environmental behaviors are positively framed, people see benefits about the environment but also their own health.”

The study’s findings could be especially relevant in coastal regions that need to curb littering before it becomes marine debris and pollutes the ocean, the researchers say.

Researchers conducted two surveys with more than 1,000 US adults living in coastal regions ranging from Georgia to California.

Individuals were first asked to consider both personal barriers to volunteering to help clean up the environment and possible positive outcomes with participating. They were asked to finish the sentence: “If I pick up trash while being active outdoors, I am likely to…” to gauge those feelings. People answered these questions with responses like: “I am likely to meet new people” or “I am likely to feel more fit afterwards.”

The second survey asked the same coastal residents about present and future pro-environmental actions and beliefs, as well as their physical activity levels. For example, participants were asked how likely they would be to pick up litter in response to messages about protecting marine life or cleaning up beaches, as well as gaining physical and mental health benefits (like heart health and lower stress).

Across both surveys, connecting coastal cleanup to something positive like improved physical fitness resonated with the participants.

People said they would be more eager to help clean up their coastal community if the message language was less focused on problems associated with marine debris and its negative impacts on the environment and more focused on human reward: social, mental, and physical well-being benefits. When those benefits were spelled out, people said they would be more likely to pick up litter in the future.

“There is potential to engage new audiences in litter prevention through campaign messages focused on these positive benefits,” says Katy Smith, coauthor of the study and a public service associate with UGA Marine Extension and Georgia Sea Grant.

“We can use this to help promote environmental stewardship by showing the personal satisfaction gained in protecting the outdoor spaces we care about.”

The framing was particularly effective on those who said they were already physically active. People who believed combining cleanup efforts with exercise would lead to a better workout or even help them lose weight were more likely to add picking up litter when outdoors over the next few months.

Respondents who said they regularly participate in moderate-to-vigorous intensity exercise especially considered bending over, lifting, and any other action involved in cleanup as a win-win for both themselves and the environment.

“Picking up litter can have immediate physical health benefits because you’re walking, bending, reaching, and using fine motor control. It’s a form of functional fitness,” Gay says.

“Whether you’re out and you see a water bottle to pick up, or you’re going out for an hour or two and picking up trash, considering that physical activity component can prioritize those behaviors in the thinking process.”

Those who identified as less active found different benefits involved with cleanup appealing.

They were still enticed by positive outcomes but were more likely to commit to cleanup efforts if they saw perks in aspects of community or efficiency, not just physical activity. These participants viewed picking up litter as an opportunity to meet new people.

People who reported being less physically active saw feelings of belonging and pride as positive effects of litter cleanup. Knowing their efforts helped make their town more beautiful instilled a feeling of accomplishment.

“Being in nature or natural spaces without trash makes people feel less stressed and more connected to nature,” Gay says. “The absence of litter in your environment can build social cohesion and make people feel like they’re more part of a community.”

The study suggests that messaging development can make a key difference in the health of the environment. The more people contribute to clean up, the less likely it is that garbage will make its way into our oceans.

“Litter cleanups have direct positive impacts in our communities and the ocean,” Smith says. “They not only improve the aesthetics of our neighborhoods and outdoor spaces, but they also prevent litter from becoming marine debris. Marine debris prevention begins on land, and everyone can play a part with small daily actions, like participating in litter cleanups in the outdoor spaces they enjoy.”

The study appears in Environment and Behavior.

Additional coauthors are from UGA and the University of California, Santa Barbara.

Source: University of Georgia

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Stress plays a role in women’s long COVID

Stress appears to play a role in women with young children who are diagnosed with post-acute sequelae of the SARS-CoV-2 infection, known as Long COVID, and those who report having Long COVID symptoms.

This finding, revealed from the results of 2,500 US women who completed an online survey in July 2023, is reported with related findings in an article published in Health Psychology.

Developed by a team of researchers at Stony Brook University co-led by Marci Lobel and doctoral student Darya Likhacheva, the study examines the experience of Long COVID from a health psychology lens.

Long COVID continues to be a public health concern, yet most research involves work centered on biomedical risk factors, with little attention to the psychosocial stress processes and social relationships that could contribute to the long-term condition. Additionally, women bear a disproportionate burden of Long COVID, and gender-specific mechanisms potentially related to the condition remain poorly understood.

The research team used the survey to investigate stress, social support, and Long COVID in women who had a previous COVID-19 infection. All survey respondents were mothers of young children. Nearly 10% reported that they had Long COVID, but it was not diagnosed, and 1.2% reported they had an official diagnosis of the condition.

In summary, the survey findings showed that women who were highly stressed were more likely to have an official or self-diagnosis of Long COVID. They also had more symptoms such as fatigue, memory problems, and shortness of breath than women with lower stress as indicated in the survey. Women with more than two children experienced more Long COVID symptoms than mothers of one or two children.

The survey results also showed that stress links to Long COVID symptoms and diagnostic status were weaker among women who reported that they are well-supported by their partner, family, or friends, yet this finding according to the team appeared tenuous.

“While we cannot know for sure the actual role of stress in the development of Long COVID, or the perceived condition in these women, our study illuminates the gaps in diagnosis and healthcare for women by capturing experiences of symptoms that may not have been formerly recognized by their healthcare providers,” says Lobel, senior author and a professor in the psychology department at Stony Brook University.

“Additionally, the results demonstrate that stress is meaningfully related to Long COVID in women and may contribute to existing gender disparities.”

She explains that numerous studies find that women commonly experience negative interactions with healthcare services, often having their symptoms dismissed or minimized, resulting in underdiagnosis of conditions. Similarly, some individuals with Long COVID symptoms struggle to obtain an official diagnosis.

An important note articulated by the authors is that the study findings cannot differentiate whether stress contributes to Long COVID vulnerability or severity, or whether stress results from the symptom burden and uncertainty associated with this condition. Both, they say, are possible.

They also point out that while the findings reveal stress is meaningfully linked to Long COVID risk, symptom number, and duration in women, “associations vary across outcomes and are modified by different types of social support.”

The authors conclude that the findings, overall, “underscore the need for gender-sensitive approaches to Long COVID.”

Source: Stony Brook University

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Thousands of American landmarks face significant wildfire threat

The first national assessment of its kind reveals an urgent and largely unplanned-for threat to irreplaceable cultural heritage.

When the Palisades Fire tore through Los Angeles in January 2025, it didn’t only destroy homes. It took the Will Rogers Ranch House—a beloved California landmark—with it. Six months later, the Dragon Bravo wildfire burned through Grand Canyon National Park and destroyed the Grand Canyon Lodge, originally built in 1927. Whether either landmark will ever be meaningfully restored remains uncertain.

A new study in Nature Scientific Reports suggests these losses are not anomalies, they are an early warning.

Researchers at UC Santa Barbara’s National Center for Ecological Analysis and Synthesis (NCEAS) have completed the first national-scale assessment of wildfire risk to American cultural heritage.

Of the 100,117 sites listed on the National Register of Historic Places, more than half face measurable wildfire exposure. For 3,446 places, that risk is severe.

“These places anchor community identity, collective memory, and national heritage,” says corresponding author Caitlin Fong, a researcher at NCEAS. “Unlike homes, they cannot simply be rebuilt—and in many cases, once lost, they are gone forever.”

The study cross-referenced every mappable National Register of Historic Places sites in the US with high-resolution wildfire burn probability models, categorizing risk by place type, geographic location, and cultural significance. Explore the map to see how your favorite place scores.

Key findings include:

• Risk is most concentrated in the western United States, with additional hotspots emerging in Oklahoma, Arkansas, and along the southeastern coast.
• Buildings and historic districts—which account for 90% of all listed resources—likely face particularly acute risk, because their cultural value is inseparable from their physical form. Destroy the structure, and the heritage is gone with it.
• Nationally significant sites face disproportionately high wildfire exposure relative to state and locally significant ones, meaning America’s most important historic places are among its most vulnerable.
• In California, New Mexico, Colorado, and Oklahoma, the concentration of at-risk sites is especially acute.
• Climate change is expected to expand wildfire hazard zones, putting sites in previously lower-risk regions increasingly in the crosshairs.

The Will Rogers Ranch House and Grand Canyon Lodge offer a sobering glimpse of what’s at stake. Rebuilding portions of the Will Rogers site is projected to cost $5.1 million, with key historic elements that were evacuated now guiding reconstruction efforts. The future of the Grand Canyon Lodge, which had already been rebuilt once after a 1932 fire, remains undecided.

The study finds that cultural heritage is largely absent from dedicated wildfire planning frameworks in most states. California, through CAL FIRE’s Cultural Resources Management Program, is among the few exceptions. Elsewhere, historic sites must compete for attention within broader all-hazards planning processes not specifically designed with heritage protection in mind.

The researchers argue that the stakes extend beyond the physical loss of individual structures. Wildfire risk assessments have long focused on homes, infrastructure and ecosystems—but the cultural and psychological dimensions of what communities lose when historic places burn have rarely entered that conversation.

“The connection people have to places, their sense of place, is a profound and deeply underappreciated dimension of what communities stand to lose from wildfire,” says coauthor Benjamin Halpern, professor at UCSB’s Bren School of Environmental Science and executive director of NCEAS.

“Our study identifies where these losses are most likely to happen.”

The researchers outline several mitigation strategies compatible with historic preservation standards, including vegetation management, structural hardening with fire-resistant materials and concealed fire suppression systems that protect structures without compromising their historic character.

Critically, the study’s open-source dataset gives federal, state and local agencies a consistent, nationally comparable foundation for prioritizing which sites to protect first, before the next fire makes the decision for them.

“By identifying where and what is most at risk, this study provides a foundation for proactive planning to safeguard the places that anchor community identity and national heritage before they are permanently lost,” says lead author Mona Farnisa.

The research was funded by the Gordon and Betty Moore Foundation. Data and methodology are publicly available.

Source: UC Santa Barbara

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Hand-held gadget measures fat burning via breath

Researchers have created a portable device that detects when the body starts burning fat when dieting or during exercise.

The device detects the acetone content in exhaled breath nearly as accurately as a mass spectrometer. Acetone is the by-product of fat metabolism that is exhaled via the lungs. It is made when the body burns fat instead of carbohydrates such as sugar.

The device is very reminiscent of the alcohol breathalyzers used by the police in traffic checks and can be operated reliably by non-experts in combination with a smartphone app. People can therefore monitor their fat metabolism without professional support or blood tests.

This could eventually allow diets, treatments for metabolic disorders like diabetes, and ketogenic therapies used for example for epilepsy to be monitored more closely and tailored to individual patients.

“When it comes to diets, there’s no rule of thumb that works for everybody. Ideally, people should self-monitor to see how their own metabolism responds,” explains Andreas Güntner, professor of molecular sensing at ETH Zurich’s mechanical and process engineering department.

“Methods are also needed that can be carried out independently and that produce reliable results, similar to blood glucose measurements for diabetics.”

Güntner’s research group developed the measuring device in collaboration with the ETH spin-off Alivion, and tested its reliability together with the University Hospital Zurich.

In a validation study involving 12 adults, the researchers compared 312 breath readings recorded with the new measuring device with blood test results and measurements from a high-precision mass spectrometer—the analytical gold standard. The measurements were carried out using different metabolic scenarios: with light and intensive physical activity and various diets. This revealed that the results from the hand-held device were practically identical to those from the lab. In addition, the new measuring device delivered reliable results over a period of months.

In essence, the recently tested hand-held device is based on a sensor technology that has been in development at ETH Zurich for over 10 years and was presented for the first time in 2017. Already at the time, Güntner and his coauthors were able to demonstrate that the gas sensors they had developed were so sensitive that they could detect a single acetone molecule in a hundred million other molecules.

According to the researchers, readings from currently available acetone breathalyzers have only limited reproducibility and can only detect pronounced metabolic changes. They not only respond to acetone, but also to other components of exhaled air, for example if test subjects ate or drank something beforehand.

The researchers therefore developed a filter that blocks interfering molecules, and a smartphone app that guides test subjects in real time as they exhale.

“The device measures the volume of exhaled air and only takes a sample that comes from deep in the lungs after a certain time,” says lead author Simone Hersberger, adding: “otherwise, every reading would be slightly different.” In order for this to work, the devices are initially calibrated and adjusted to the patient’s lung volume.

The successful validation study is an important milestone for the researchers.

“We were able to demonstrate that our device can detect slight differences in fat metabolism accurately and reliably,” says ETH doctoral student Hersberger.

Further studies are now intended to show whether the new measuring device can really be used to personalise therapies for metabolic disorders. In partnership with the University Children’s Hospital Zurich, the researchers are currently looking at whether the hand-held device can help children with epilepsy better monitor their ketogenic diet. Other fields of application are the monitoring and optimization of medical diets or of so-called GLP-1 therapies with weight loss jabs. Applications in amateur sports are also being considered.

The ETH spin-off Alivion AG has launched the device under the name Nutrion. It is currently being deployed in international research studies and in medical facilities. To scale up further and to open up further fields of application, Alivion is seeking additional industry partners and strategic investors.

“This example shows how the results of basic research can be put into practice and ultimately help society,” says Güntner.

The research appears in the journal Device.

This work is being financially supported by Innosuisse, the Vontobel Foundation, and the Accentus Foundation.

Source: ETH Zurich

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New test detects deadly tick-borne disease in just 40 mins

New research is transforming how Rocky Mountain spotted fever is diagnosed.

The new method detects the deadly tick-borne disease in just 40 minutes—a leap that could help patients get lifesaving treatment sooner.

Early diagnosis of Rocky Mountain spotted fever is critical. Patients can go from a tick bite to a severe fever, headache, and rash within days. Yet existing diagnostic tools can be expensive, hard to access, or unable to detect small amounts of the bacteria in a blood sample.

The new method changes that, delivering clearer answers when they matter most.

The test, which involves mixing DNA from a sample with specialized reagents in two quick, 20-minute steps, can be completed at room temperature without the need for complex and costly laboratory equipment. After 40 minutes, a change in liquid color indicates a positive detection of the bacteria.

The antibiotic doxycycline is used to treat the disease, and clinicians often prescribe it while waiting on confirmatory testing. Right now, that can take too long.

“Unfortunately, this disease can be particularly deadly in children if diagnosis is delayed, and often patients may not realize they have been bitten by a tick until they feel extremely ill,” says Roman Ganta, a professor in the College of Veterinary Medicine and investigator in the Bond Life Sciences Center.

“Quicker diagnosis leads to quicker treatment with doxycycline, so we are hopeful our research can improve outcomes for those impacted.”

Ganta hopes this test will eventually be used in rural or under-resourced clinics around the world where the advanced laboratory equipment currently needed to detect Rocky Mountain spotted fever is inaccessible. He is in discussions with the Veterinary Medical Diagnostic Laboratory at Mizzou to see whether this test may be utilized in clinical applications in the future.

“By making this test more accessible, more patients can benefit from our work one day,” Ganta says.

The study appears in Frontiers in Microbiology.

Source: University of Missouri

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