The chemicals that flavor vape liquid damage DNA

New research unpacks the list of chemicals that comprise flavored e-liquids and pods for vaping and details their harmful effects to lung tissue.

These effects include inflammation and genetic damage that could indicate long-term risk for respiratory disease and even cancer.

“While names like mango, cucumber, and mint give the impression that the flavors in e-juices are benign, the reality is that these sensations are derived from chemicals,” says lead author Irfan Rahman, a professor in the department of environmental medicine at the University of Rochester Medical Center.

“These findings indicate that exposure to these chemicals triggers damage and dysfunction in the lungs that are a precursor to long-term health consequences.”

Other than propylene glycol and vegetable glycerin, which form the base of vaping liquids, and nicotine, most manufacturers do not disclose the chemical compounds used to create the flavors in vaping products.

Employing mass spectrometry, the researchers identified almost 40 different chemicals present in various combinations in seven flavors manufactured by Juul. These include hydrocarbons and volatile organic compounds, many of which have industrial uses and are known to be harmful if inhaled.

Juul—which accounts for more than 70% of all vaping product sales in the US—has recently halted sales of most of its flavored pods and several states, including New York, are in the process of banning these products. However, many other companies and independent vape shops continue to manufacture and sell an estimated 8,000 different flavored e-juices and pods.

In the study, researchers exposed human lung tissue—including bronchial epithelial cells, which play an important role in the exchange of gases, and monocytes, an infection-fighting cell in the immune system—to aerosolized vapor from the flavor pods. They observed that the chemicals provoked inflammation and degraded the integrity of the epithelial cells, a condition that could eventually lead to acute lung injury and respiratory illness.

Exposure also damaged DNA in the cells, a potential precursor to cancer. The study shows that menthol flavor, which Juul continues to sell, is equally as harmful as other flavors.

“Vaping technology has only existed for a short period of time and its use, particularly among younger people, has only recently exploded,” says Rahman. “This study gives further evidence that vaping—while less harmful than combustible tobacco in the short run—is placing chronic users on the path to significant health problems later in life.”

The paper appears in the journal Scientific Reports. Additional coauthors are from URMC and the College of Brockport.

Support came from the National Cancer Institute and CRoFT.

Source: University of Rochester

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