Mice ‘dream’ about the world just before they’re born

A new study with mice suggests that, in a sense, mammals dream about the world they are about to experience before they are even born.

As a newborn mammal opens its eyes for the first time, it can already make visual sense of the world around it. But how does this happen before they have experienced sight?

Writing in the journal Science, researchers led by Michael Crair, professor of neuroscience and professor of ophthalmology and visual science at Yale University, describe waves of activity that emanate from the neonatal retina in mice before their eyes ever open.

This activity disappears soon after birth and is replaced by a more mature network of neural transmissions of visual stimuli to the brain, where information is further encoded and stored.

“At eye opening, mammals are capable of pretty sophisticated behavior,” says Crair, who is also vice provost for research.” But how do the circuits form that allow us to perceive motion and navigate the world? It turns out we are born capable of many of these behaviors, at least in rudimentary form.”

In the study, Crair’s team, led by graduate students Xinxin Ge and Kathy Zhang, explored the origins of these waves of activity. Imaging the brains of mice soon after birth but before their eyes opened, the team found that these retinal waves flow in a pattern that mimics the activity that would occur if the animal were moving forward through the environment.

“This early dream-like activity makes evolutionary sense because it allows a mouse to anticipate what it will experience after opening its eyes, and be prepared to respond immediately to environmental threats,” Crair notes.

Going further, the researchers also investigated the cells and circuits responsible for propagating the retinal waves that mimic forward motion in neonatal mice. They found that blocking the function of starburst amacrine cells, which are cells in the retina that release neurotransmitters, prevents the waves from flowing in the direction that mimics forward motion. This in turn impairs the development of the mouse’s ability to respond to visual motion after birth.

Intriguingly, within the adult retina of the mouse these same cells play a crucial role in a more sophisticated motion detection circuit that allows them to respond to environmental cues.

Mice, of course, differ from humans in their ability to quickly navigate their environment soon after birth. However, human babies are also able to immediately detect objects and identify motion, such as a finger moving across their field of vision, suggesting that their visual system is also primed before birth.

“These brain circuits are self-organized at birth and some of the early teaching is already done,” Crair says. “It’s like dreaming about what you are going to see before you even open your eyes.”

Source: Yale University

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