Sleep problems may get worse as kids with epilepsy age

Not only are reported sleep concerns highly prevalent in children with epilepsy—for both those with and without nighttime seizures—but these issues persist and may potentially even get worse with age, according to a new study.

“We know sleep disorders are common, and sometimes severe, for children with early-life epilepsies but there’s a huge gap in data on how often this is a problem and who may be at highest risk,” says lead author Gita Gupta, a pediatric pulmonology fellow at the University of Michigan Health C.S. Mott Children’s Hospital.

“Our findings suggest that sleep disturbances and their complications are highly pervasive in children with epilepsy, and these sleep problems continue as they get older.”

Kids with epilepsy struggle to sleep

Researchers analyzed responses from parents of 356 children with epilepsy between newborn age and 13 years old, with an average age of four and a half, through the national Rare Epilepsy Network survey.

More than half of respondents reported sleep concerns, with 45% worried about frequent nighttime awakenings and more than a third saying their child had difficulty falling asleep or had very restless sleep. Three-fourths of children’s sleep was disrupted by nighttime seizures, according to the findings in Pediatric Neurology.

Of the children without nocturnal seizures, 43% (38 of 88) had sleep concerns, and these were most commonly reported for those with Dravet syndrome, a rare, drug-resistant epilepsy that begins in the first year of life and can cause varying degrees of developmental disability.

Girls also appeared to be less likely to face sleep issues than boys, which could be connected to various genetic factors, authors say, but that needs further study.

Nighttime awakenings, difficulty falling asleep, and restless sleep also happen to be the most prevalent sleep concerns reported by parents of typically developing children aged 0 to 36 months, the study finds. But for healthy children, sleep issues often begin to wane after they turn six months old, Gupta says.

“Sleep concerns are expected during the newborn and early stages of childhood when parents are often up with their babies and toddlers at night,” Gupta says. “But while healthy children usually grow out of these phases, children with epilepsy continue to struggle with sleep.”

Children with epilepsy also have a higher prevalence of excessive daytime sleepiness, and sleep apnea symptoms than typically developing children, the study suggests.

Better epilepsy management

Experts say there appears to be a strong yet understudied link between sleep and epilepsy, which generally comes with a higher risk for sleeping disorders like obstructive sleep apnea, circadian rhythm disorders, irregular sleep/wake patterns, and insomnia.

For some children with epilepsy, sleep deprivation also provokes seizures and certain sleep disorders can worsen the frequency and severity of seizures.

The researchers note that further study should explore whether sleep disorders and epilepsy may share common neurophysiological pathways, which may potentially open new doors for target interventions and ways to enhance epilepsy management.

“The better we understand the relationship between sleep problems and epilepsy the better we can treat children with these conditions and improve their overall quality of life,” says senior author Renée Shellhaas, a pediatric neurologist at Mott.

“Our study reinforces what we consistently hear from parents about sleep challenges and highlights the unmet clinical need for sleep interventions among children with epilepsy. Without treatment, these kids may go on to face worsening sleep issues that could disrupt all areas of their health.”

While sleep plays a crucial role in child development with both short- and long-term consequences, Gupta says, sleep issues aren’t always addressed during epilepsy treatment.

“Sleep impacts every sphere of our lives from early childhood development and neurodevelopment to attention, mood, and cardiovascular health,” Gupta says. “As children get older, sleep deprivation may not only negatively affect physical health and development but may also interfere with schoolwork, socialization, and safety.”

When a child’s sleep suffers, she notes, it can affect caregivers’ sleep as well. Parents may co-sleep with children, sleep in the same room, or constantly monitor them at night, habits that could develop into unhealthy sleep practices that worsen sleep outcomes for everyone.

“Poor sleep not only has health and quality-of-life consequences for the child but likely affects the whole family,” she says. “Our greatest goal is to optimize epilepsy management and outcomes in kids with relatively low-risk, noninvasive interventions that benefit both them and their families.”

Source: University of Michigan

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