Does THC as a teen stymie female reproductive health later?

Exposure to THC, a component of cannabis, at a young age could lead to depleted ovarian follicles and matured eggs in adulthood by nearly 50%, a new study with mice shows.

The findings show that the use of cannabis earlier in a female’s life could have long-term effects on her ability to conceive.

“Given that more and more teenagers and young adults are using cannabis, especially with easier access to the substance, this study’s findings are especially important,” says Ulrike Luderer, professor of environmental and occupational health at the University of California, Irvine Program in Public Health and senior and corresponding author of the study in Toxicological Sciences.

“It is imperative to widely broadcast the consequences of early-life exposure to cannabis on reproductive health in adulthood.”

Roughly 3.3 million adolescents aged 12 to 17 and 4.8 million people aged 12 and older reported using cannabis, based on a 2019 survey. Up until this point, very few studies have been conducted that demonstrate the long-term negative public health impacts of cannabis use, and even more unclear are the reproductive health implications on women.

The researchers used a mouse model to test their hypothesis that THC (tetrahydrocannabinol) can cause adverse health effects in adulthood. They started by injecting THC into immature mice for a period of two weeks and evaluated the effects on their models at different time periods post-injection. They found that the number of healthy ovarian follicles decreased by nearly 50% in primordial follicles, which are the fundamental reproductive units of the ovary and are non-renewable.

The researchers suspect that the dramatic drop in ovarian follicle numbers was caused by accelerated activation of resting follicles, followed by DNA-damage-associated death of follicles at later stages of development.

These effects are likely mediated by the endocannabinoid system (ECS), a signaling complex that serves a vast array of bodily functions in mammals. In line with this, the researchers also found that the ECS component proteins called cannabinoid receptor type 1 (CB1R) and type 2 (CB2R), which THC and its active metabolites activate, are present in ovarian follicles.

“Our findings provide unexpected new insights into the long-term impact of THC on reproductive function and aging,” says coauthor Daniele Piomelli, professor of anatomy and neurobiology at the UCI School of Medicine. “Our hope is that our findings will motivate teenage girls to make better, more informed decisions about whether or not to ingest cannabis products.”

Additional coauthors are from Indiana University-Bloomington and UC Irvine.

The National Institute on Drug Abuse Center, the National Institute for Health, and the Impact of Cannabinoids across the Lifespan Pilot Grant funded the work.

Source: UC Irvine

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